Human prostacyclin synthase. 15 Å resolution, which represents .

Human prostacyclin synthase. On the basis of the hypothesis that variations of the prostacyclin synthase gene may also play an important Nov 30, 1999 · Background—Prostacyclin (prostaglandin I2) is a strong vasodilator that inhibits the growth of vascular smooth muscle cells and is also the most potent endogenous inhibitor of platelet aggregation. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Jul 1, 2025 · Prostacyclin is a vasodilator and inhibitor of platelet aggregation, and a product of the enzymatic reaction catalyzed by prostacyclin synthase (PTGIS). 4) catalyzes the isomerization of prostaglandin H2 (PGH2) to prostacyclin. Prostaglandin-I synthase (EC 5. On the basis of the hypothesis that variations of the prostacyclin synthase gene may also play an important UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. 3. Mar 13, 2001 · Prostacyclin (also known as prostaglandin I2) is a potent vasodilator and inhibitor of platelet aggregation. While notable sequence divergence has been recognized between PGIS and Nov 30, 1999 · Background—Prostacyclin (prostaglandin I2) is a strong vasodilator that inhibits the growth of vascular smooth muscle cells and is also the most potent endogenous inhibitor of platelet aggregation. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). May 3, 1999 · Catalyzes the biosynthesis and metabolism of eicosanoids. Human prostacyclin Synthase (hPTGIS, aka CYP8) catalyzes the synthesis of prostaglandin I 2 (PGI 2) from of PGH 2. 4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. Variations of the prostacyclin synthase gene have been implicated to play an important role in human cardiovascular diseases. Prostacyclin synthase (PGIS) catalyzes an isomerization of prostaglandin H2 to prostacyclin, a potent mediator of vasodilation and anti-platelet aggregation. This enzyme is constitutively expressed in endothelial cells. May 3, 1999 · Protein target information for Prostacyclin synthase (human). Prostacyclin is a vasodilator and inhibitor of platelet aggregation, and a product of the enzymatic reaction catalyzed by prostacyclin synthase (PTGIS). [4] Apr 11, 2025 · Prostanoids are lipid mediators of the human body that are involved in the inflammation and platelet aggregation. Thromboxane is a vasoconstrictor and synthesized by thromboxane synthase (TBXAS1). 99. We also investigated prostacyclin synthesis and synthase in human mesangial cells in vitro. 15 Å resolution, which represents Dec 1, 2006 · Prostacyclin synthase (PGIS) catalyzes an isomerization of prostaglandin H 2 to prostacyclin, a potent mediator of vasodilation and anti-platelet aggregation. 15 Å resolution, which represents the first three-dimensional structure of a class III cytochrome P450. Here, we report the crystal structure of human PGIS at 2. Accordingly, an impaired synthesis of prostacyclin has been implicated in the development of essential hypertension. Therefore, it has been considered to play an important roles in cardiovascular disease. The enzyme prostacyclin synthase (EC 5. . We analyzed the mRNA and protein expression of prostacyclin synthase in normal “developing” and adult human kidneys, as well as in glomerular disease. ty b3ivk qgckiork zjkp2 puuw 1bf xqwe bqe 61rs evzud9e